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Predicting intentions towards long-term antidepressant use in the management of people with depression in primary care: A longitudinal survey study
Background Over the last two decades, antidepressant prescribing in the UK has increased considerably, due to an increased number of people staying on antidepressants for longer. Even when treatment is no longer clinically indicated, qualitative research suggests many people continue due to a fear of depr…
Adapting the Germ Defence Web-Based Intervention to Improve Infection Prevention and Control in Care Homes: Interview Study Among Care Home Staff
Background: Infection prevention and control (IPC) is vital in care homes as it can reduce morbidity and mortality by 30%. Ensuring good IPC practice is a perennial challenge in the varied and complex context of care homes. Behavior change interventions delivered via digital technology may be effective in im…
Cardiovascular disease burden and risk factor management in cancer survivors: insights into a multiethnic, socioeconomically deprived urban population
Background Cardiovascular disease (CVD) burden and risk factor management among cancer survivors, especially in socioeconomically deprived, multiethnic populations, remain understudied. This study examines CVD burden and risk factor control in survivors of 20 cancer types within a diverse urban population…
Interventions that prevent or reduce perinatal loneliness and its proximal determinants: a restricted scoping review
Background The World Health Organisation’s Commission on Social Connection (2024–2026) highlights the importance of addressing loneliness because of its negative impact on health and well-being. The perinatal period carries an increased risk of loneliness for mothers and fathers which is elevated by intersect…
A Co-produced International Qualitative Systematic Review on Lived Experiences of Trauma During Homelessness in Adulthood and Impacts on Mental Health
Abstract Trauma can be both a cause and a consequence of homelessness and has lasting impacts on mental health and wellbeing. Often research focusses on trauma and adversity in childhood leading to homelessness, but understanding traumatic experiences during adulthood homelessness can be just as imp…
The Management of Chronic Insomnia in Young Children: A Survey of UK General Practice
ABSTRACT Objectives Chronic insomnia (CI), the most common sleep disorder in young children, is associated with negative outcomes for the child and family. This study explores the beliefs, current practice, and understanding of UK primary health care professionals (PCPs) regarding CI in children under 5…
Technostress, technosuffering, and relational strain: a multi-method qualitative study of how remote and digital work affects staff in UK general practice.
Abstract Background The introduction of remote and digital forms of working in UK general practice has driven the development of new routines and working styles. Aim To explore and theorise how new forms of work have affected general practice staff. Design and setting Multi-sited, qualitative case study in UK…
Mortality in adolescents after therapeutic intervention for self-harm: A systematic review and meta-analysis
Background Self-harm in adolescents is an international concern. Evidence highlights that therapeutic intervention (TI), such as cognitive behaviour therapy informed treatments, after self-harm leads to reduced self-harm repetition. However, there is no prior literature about the effects of TI on future mortality i…
plaTform fOr Urinary tract infection diagnostiC evAluatioN (TOUCAN): a protocol for a prospective diagnostic accuracy study of point-of-care testing in patients suspected of acute uncomplicated urinary tract infection in primary care clinics in England
Abstract Introduction Acute uncomplicated urinary tract infection (UTI) is a common condition with potentially serious sequelae that is mostly diagnosed and managed in primary care settings. Around half of all women have a UTI in their lifetime, and a quarter experience an infection caused by organisms resista…
Do community-based digital health inclusion programmes contribute to tackling health inequalities in disadvantaged population groups?: a qualitative study of experiences of a city-wide programme in the North of England.
Background Advances in digital healthcare and health information provide benefits to the public. However, lack of digital skills together with access, confidence, trust and motivation issues present seemingly insurmountable barriers for many. Such digital health exclusion exacerbates existing health ineq…
Temporal trends and practice variation of paediatric diagnostic tests in primary care: retrospective analysis of 14 million tests
Abstract Objective: The primary objective was to investigate temporal trends and between-practice variability of paediatric test use in primary care. Methods and analysis: This was a descriptive study of population-based data from Clinical Practice Research Datalink Aurum primary care consultation records from…
Developing a quality framework for community pharmacy: a systematic review of international literature
Abstract Background We conducted a mixed methods evaluation to assess whether implementing a primary care quality improvement (QI) programme utilising a digital call-and-recall tool improved timely receipt and equity of first measles, mumps and rubella (MMR) and diphtheria tetanus, pertussis and pol…
The prevalence and determinants of health anxiety during the covid-19 pandemic: A systematic review and meta-analysis
Abstract The coronavirus disease 2019 (COVID-19) pandemic subjected the global population to a situation that aroused disproportionate Health Anxiety (HA). However, this association has not been explored in a systematic review or meta-analysis. The aim of this systematic review was to assess the prevalence a…
Service delivery and the role of clinical pharmacists in UK primary care for older people, including people with dementia: a scoping review
Abstract Objective As populations age globally, there is increasing prevalence of multiple long-term conditions, such as dementia, leading to many challenges. The burden on health and care services, economic pressures, and the necessity for innovative policies to better support older people and peopl…
The role of Black-led community organisations in supporting Black mental health: a Black emancipatory action research project
ABSTRACT Objective To explore the role of Black-led community organisations in supporting Black mental health and wellbeing in the UK. Design A qualitative, Black Emancipatory Action Research Framework was adopted. Framework application involved adequately compensating community organisations for their…
Risk of Parkinson’s disease in people aged ≥50 years with new-onset anxiety: a retrospective cohort study in UK primary care
Abstract Background A history of anxiety is more common in people with Parkinson’s disease (PD). The prospective risk of PD in those newly presenting with anxiety and factors that increase the risk of PD in patients with anxiety have not been investigated. Aim To investigate the incidence of PD in people with an…
Defining Mental Health Conditions Within Primary Care Data: A Validation Study With a Mixed Qualitative and Quantitative Approach
ABSTRACT Objectives To validate codelists for defining a range of mental health (MH) conditions with primary care data, using a mixed qualitative and quantitative approach and without requiring external data. Methods We validated Read codelists, selecting and classifying them in three steps. The qualitati…
Biomarkers Suitable for Early Detection of Intrathoracic Cancers in Primary Care: A Systematic Review
Abstract Intrathoracic cancers, including lung cancer, mesothelioma, and thymoma, present diagnostic challenges in primary care. Biomarkers could resolve some challenges. We synthesized evidence on biomarker performance for intrathoracic cancer detection in low-prevalence settings. A search in Embase an…
Experiences and impact of moral injury in prisons
ABSTRACT Moral injury is the persistent mental or emotional distress resulting from events that challenge one’s moral beliefs. It is characterised by intense shame, guilt, worthlessness, disgust or anger and can contribute towards the development of serious mental disorders. The nature of working in prisons me…
Involving People With Lived Experience in Electronic Health Record Database Studies Reflections and Learning From the CHOOSE Study
Abstract Background: Patient and public involvement and engagement (PPIE) is integral to health research. Reporting of PPIE methods and impact is becoming increasingly common in health research. However, reporting on PPIE in studies using large, routinely collected electronic health record data sets…